most problems in recent years are related to the possibility of a link between hormone replacement therapy and breast cancer. Studies show a 30% increase in the risk of breast cancer after 10 years of hormone replacement therapy. For example, a woman with risk of 9:100 for breast cancer, will have a risk of 12:100 after 10 or 15 years of hormone replacement.

• 출처: http://www.doctortipster.com/4995-premature-ovarian-failure-causes-risk-factors-complications-and-treatment.html