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med:azole [2014/03/13 07:05] – V_L | med:azole [2016/07/10 09:50] (현재) – 바깥 편집 127.0.0.1 | ||
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+ | {{tag> | ||
+ | ======아졸 (Azole)====== | ||
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+ | ^ Imidazoles vs. Triazoles | ||
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+ | Because ergosterol is present in cell membranes of fungi, yet absent in those of animals, it is a useful target for antifungal drugs. | ||
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+ | The difference between the imidazoles and the triazoles involves the mechanism of inhibition of the cytochrome P450 enzyme. The N3 of the imidazole compound binds to the heme iron atom of ferric cytochrome P450, whereas the N4 of the triazoles bind to the heme group. The triazoles have been shown to have a higher specificity for the cytochrome P450 than imidazoles, thereby making them more potent than the imidazoles. | ||
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+ | The triazole antifungal drugs include fluconazole, | ||
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+ | * [[wp> | ||
+ | * [[wp> | ||
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+ | * [[wp> | ||
+ | * [[wp> Tinidazole]] | ||
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+ | The substituted imidazole derivatives are valuable in treatment of many systemic fungal infections. | ||
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+ | Imidazoles belong to the class of azole antifungals, | ||
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+ | For comparison, another group of azoles is the triazoles, which includes fluconazole, | ||
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+ | Many drugs contain an imidazole ring, such as antifungal drugs, nitroimidazole, | ||
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+ | * Triazole antifungals: | ||
+ | * Imidazole antifungals: | ||
+ | * Polyene antifungals: | ||
+ | * Echinocandin antifungals: | ||
+ | * Other antifungals: | ||
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+ | =====상호작용===== | ||
+ | * There were no interactions found in our database between Flagyl IV and fluconazole | ||
+ | * There are no known interactions between | ||
+ | * | ||
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