문서의 이전 판입니다!
이 문서는 의학지식을 포함하고 있습니다. 의학은 빠르게 변화하는 학문으로 아래의 내용은 최신의 정보가 아닐 수 있으며, 따라서 글을 읽는 시점에는 정확한 내용이 아닐 수 있습니다. 이 내용에 따라 스스로 질병을 진단하거나 치료하려 하지 마십시오. 질병의 정확한 진단과 치료를 위해서는 의사의 진료가 필수적입니다. 이 내용은 의학적 상식을 넓히기 위한 용도로 사용하십시오.
임신중독증 저용량아스피린
효과
적응증
고위험
아래에 하나라도 해당할 경우 저용량 아스피린 요법 권장.
- 자간전증 (Preeclampsia)의 과거력
- 당뇨병 (1형 혹은 2형)
- 신장질환 (Renal disease)
- 자가면역질환 (Autoimmune disease) (전신성 홍반성 루프스 (Systemic Lupus Erythematosus; SLE), antiphospholipid syndrome)
중등도
아래의 항목 두 개이상 해당할 경우 권장.
- 초산모 (Nulliparity; never having given birth)
- 비만 (body mass index >30 kg/m2)
- 임신중독증 가족력 (mother or sister)
- Sociodemographic characteristics (African American race, low socioeconomic status)
- Age ≥35 years
- Personal history factors (e.g., low birthweight or small for gestational age, previous adverse pregnancy outcome, >10-year pregnancy interval)
저위험
이전에 합병증 없는 만삭 분만한 경우 권장하지 않음.
안전성
No increase in infant loss, growth problems, or cognition harm to the baby; No statistically significant impact on risk of placental abruptions, postpartum hemorrhage (bleeding), or miscarriage to the mother; No differences in developmental outcomes of the infants up to age 18 months.
복용시작시기
보통 임신 12주에서 16주 사이에 복용을 시작한다. 6)
중단시기
When should I stop taking low-dose aspirin? It is very important that you ask your doctor when you should stop taking aspirin, as recommendations may be differ depending on your medical history.
There are opposing arguments regarding when to discontinue aspirin treatment. Some argue that aspirin should be discontinued at 36 weeks because of the possible bleeding risks associated with delivery.
Others argue, because most preeclampsia occurs after 36 weeks, that the aspirin may be beneficial to continue through delivery, into the postpartum period.
More research is needed, but again, it is imperative you discuss a stopping point with your healthcare professional if you are on a prenatal aspirin regimen.
1)
Low-dose 아스피린 ranges from 60-150 mg daily but, in the United States, the usual dose is a 81-mg tablet
2)
found a 2 to 5% risk reduction in the rate of preeclampsia
3)
A review of 45 randomized trials that included over 20,000 pregnant women taking daily low-dose aspirin showed significant evidence of the prevention of preeclampsia, severe preeclampsia, and fetal growth restriction when initiated before 16 weeks’ gestation.
4)
Low-dose aspirin initiated after 16 weeks’ gestation may not be as effective at reducing the risk of preeclampsia, severe preeclampsia, and fetal growth restriction
5)
Women at high risk for those outcomes should be identified in early pregnancy
6)
You should start taking low-dose aspirin between weeks 12 and 16 of your pregnancy